The Substance

2024 "Have you ever dreamt of a better version of yourself?"

Watch Now

The Substance

7.2 | 2h21m | R | en | Horror

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Watch with Prime Video
30 days Free

WATCH NOW

Stay Updated

Get tailored updates on new movies and shows. Never miss a release!

7.2 | 2h21m | R | en | Horror , Thriller , Science Fiction

Synopsis

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Cast

Demi Moore , Margaret Qualley , Dennis Quaid

Director

Krystell Morantin

Producted By

Working Title Films , Working Title Films

Stream over
800,000 titles
with Prime Video

30-day Free Trial, cancel anytime

Watch Now

Watch Now on Prime Video

7-day Free Trial, cancel anytime

Watch Now

Trailers

Watch full movie online Watch Now

Cast

Demi Moore

as Elisabeth

[2026] Yellow Mirror [2026] I Love Boosters [2026] Groundswell [2025] Emma and Bruce Willis: The Unexpected Journey – A Diane Sawyer Special [2025] Ghost [2025] Inside the Screenplay of The Substance [2024] Landman [2024] The Substance [2024] BRATS

Margaret Qualley

as Sue

[2026] The Dog Stars [2026] How to Make a Killing [2026] Romeo + Juliet [2025] Blue Moon [2025] Honey Don't! [2025] Oddwadd [2024] Drive-Away Dolls [2024] Possessing Beauty: The Making of Poor Things [2024] The Substance

Dennis Quaid

as Harvey

[2026] I Can Only Imagine 2 [2026] War Machine [2026] The Florist [2026] Signal One [2025] Broke [2025] Sovereign [2025] Happy Face [2025] Twin Towers: Legacy [2025] Saurus City