The Substance

2024 "Have you ever dreamt of a better version of yourself?"

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The Substance

7.2 | 2h21m | R | en | Horror

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

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7.2 | 2h21m | R | en | Horror , Science Fiction

Synopsis

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Cast

Demi Moore , Margaret Qualley , Dennis Quaid

Director

Krystell Morantin

Producted By

Working Title Films , Working Title Films

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Trailers

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Cast

Demi Moore

as Elisabeth

[2025] Ghost [2025] The Making of The Substance [2025] Inside the Screenplay of The Substance [2024] Carnet de Voyages p.1 : Festival de Cannes [2024] Feud: Capote vs. The Swans [2024] Landman [2024] The Substance [2024] BRATS [2022] The Unbearable Weight of Massive Talent

Margaret Qualley

as Sue

[2025] Blue Moon [2025] Honey Don't! [2025] The Making of The Substance [2024] The Button [2024] The 66th Annual Grammy Awards [2024] Drive-Away Dolls [2024] Possessing Beauty: The Making of Poor Things [2024] The Substance [2024] Kinds of Kindness

Dennis Quaid

as Harvey

[2025] Broke [2025] Sovereign [2025] Happy Face [2025] The Making of The Substance [2024] The Long Game [2024] The Substance [2024] Reagan [2023] Full Circle [2023] On a Wing and a Prayer