The Substance

2024 "If you follow the instructions, what could go wrong?"

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The Substance

7.4 | 2h21m | R | en | Horror

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

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7.4 | 2h21m | R | en | Horror , Thriller , Science Fiction

Synopsis

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Cast

Demi Moore , Margaret Qualley , Dennis Quaid

Director

Krystell Morantin

Producted By

Working Title Films , Blacksmith

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Trailers

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Cast

Demi Moore

as Elisabeth

[2022] The Unbearable Weight of Massive Talent [2022] Please Baby Please [2020] Savage X Fenty Show Vol. 2 [2020] Songbird [2019] Corporate Animals [2019] I Am Patrick Swayze [2018] Comedy Central Roast of Bruce Willis [2018] Love Sonia [2017] Rough Night

Margaret Qualley

as Sue

[2022] Stars at Noon [2021] Maid [2021] My Salinger Year [2019] Fosse/Verdon [2019] Once Upon a Time... in Hollywood [2019] Adam [2019] Donnybrook [2019] Seberg [2019] Native Son

Dennis Quaid

as Harvey

[2022] The Tiger Rising [2021] American Underdog [2021] Born a Champion [2021] Blue Miracle [2020] John Bronco [2019] The Intruder [2019] Merry Happy Whatever [2019] A Dog's Journey [2019] Midway